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As more IT and OT systems are converged, the opportunity for cyber events that result in disruption or misuse could mean significant damage—physical, financial, environmental, and/or health and safety. OT-dependent organizations should be thinking twice about how to adopt innovative technologies and devices and leverage a security approach as an enabler of safe and secure operations. The ISA/IEC-62443 series of standards is a framework designed to secure operations and protect OT environments. Using the Zero Trust five-step methodology will simplify the implementation of these standards, enabling organizations to improve security of their critical OT systems using an iterative approach.